Free CNS Neuroprotection (Handbook of Experimental Pharmacology)
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Book Details :
Published on: 2002-08-15
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Original language: English
"CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain. " Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in acute and chronic human neurodegenerative conditions. While the outcomes of these trials have not been as successful as initially hoped, these were early explorations, and the pipeline of relevant ideas continues to grow in strength and depth. We predict that early in this new millennium, crippling disorders such as stroke and Alzheimer's disease will be treated effectively by therapeutic neuroprotective strategies. This volume of the Handbook of Experimental Pharmacology titled eNS Neuroprotection provides a pharmacological perspective on currently promis ing neuroprotective approaches, and a clinical perspective on the challenges involved in establishing the efficacy of these approaches through appropriate clinical trials. Section I, "Mechanistic Approaches to CNS Neuroprotection," reviews major injury mechanisms that have formed the basis for many past and present clinical trials conducted around the world. Dr. KIM and colleagues, Washington University School of Medicine, review the status of blocking excitotoxicity as an approach to CNS neuroprotection. Dr. WANG, Pfizer Global Research and Development,Ann Arbor Laboratories, outlines evidence supporting a contri bution of apoptosis to pathological neuronal or glial cell loss. Drs. BECKER and HALLENBECK, University of Washington and the National Institute on Neuro logical Diseases and Stroke, respectively, argue that inhibiting inflammatory pathways in the brain can be neuroprotective. Dr. Gua basada en la evidencia de la Asociacin Psiquitrica ... Objetivos. La carga de los trastornos mentales se ha incrementado en todas las sociedades prevaleciendo al mismo tiempo variaciones en su tratamiento en un mismo ... Oral Fingolimod or Intramuscular Interferon for Relapsing ... Original Article. Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis. Jeffrey A. Cohen M.D. Frederik Barkhof M.D. Giancarlo Comi M.D ... Valproate - Wikipedia Terminology. Valproic acid (VPA) is an organic weak acid. The conjugate base is valproate. The sodium salt of the acid is sodium valproate and a coordination complex ... Multiple Sclerosis NEJM More than 100 years has passed since Charcot Carswell Cruveilhier and others described the clinical and pathological characteristics of multiple sclerosis. 1 This ... PROF IAN EVERALL - The University of Melbourne Overview; Publications; Research; Awards; Linkages; Supervision; Overview OverviewText1 . Professor Ian Everall obtained his MBChB at Leicester University School of ... Resolve a DOI Name Type or paste a DOI name into the text box. Click Go. Your browser will take you to a Web page (URL) associated with that DOI name. Send questions or comments to doi ... Memantine - Wikipedia Memantine is the first in a novel class of Alzheimer's disease medications acting on the glutamatergic system by blocking NMDA receptors. It was first synthesized by ...
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